Resolving inflammation by using nutrition therapy

Toll-Interacting Protein in Resolving and Non-Resolving Inflammation

Innate leukocytes manifest dynamic and distinct inflammatory responses upon challenges with rising dosages of pathogen-associated molecular pattern molecules such as lipopolysaccharide (LPS). To differentiate signal strengths, innate leukocytes may utilize distinct intracellular signaling circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adapto...

Nutrition, Inflammation, and Acute Pancreatitis

Acute pancreatitis is acute inflammatory disease of the pancreas. Nutrition has a number of anti-inflammatory effects that could affect outcomes of patients with pancreatitis. Further, it is the most promising nonspecific treatment modality in acute pancreatitis to date. This paper summarizes the best available evidence regarding the use of nutrition with a view of optimising clinical managemen...

Nutrition, Inflammation, and Infectious Disease

Pathogens and their related toxins can stimulate the production of endogenous mediators leading to dysregulated reactive oxidative stress, inflammatory responses, and alterations of organ functions. Nutrition support is necessary to protect against infectious and inflammatory conditions, but the optimal nutritional formulation is still under investigation. This special issue focuses on 5 distin...

Running Head: ALTERNATIVE NUTRITION THERAPY, TURMERIC Alternative Nutrition Therapy “Turmeric”

Total synthesis of the endogenous inflammation resolving lipid resolvin D2 using a common lynchpin

The total synthesis of the endogenous inflammation resolving eicosanoid resolvin D2 (1) is described. The key steps involved a Wittig reaction between aldehyde 5 and the ylide derived from phosphonium salt 6 to give enyne 17 and condensation of the same ylide with aldehyde 7 to afford enyne 11. Desilylation of 11 followed by hydrozirconation and iodination gave the vinyl iodide 4 and Sonogashir...